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Indianapolis, IN to Santa Ana, CA Bus

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16/06/2025
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Indianapolis, IN to Santa Ana, CA by bus

The journey from Indianapolis, IN to Santa Ana, CA by bus is 2,890.27 km and takes 57 hrs 52 mins. There are 14 connections per day, with the first departure at 3:30 a.m. and the last at 11:55 p.m.. It is possible to travel from Indianapolis, IN to Santa Ana, CA by bus for as little as $162.32 or as much as $704.81. The best price for this journey is $162.32.

Lowest Price $162.32
Journey Duration 57 hrs 52 mins
Connection per Day 14
Lowest Price $162.32
Highest Price $704.81
First Departure 3:30 a.m.
Last Departure 11:55 p.m.
Distance 2,890.27 km
Departure Indianapolis, IN
Arrival Santa Ana, CA
Carriers FlixBus, Greyhound

Indianapolis, IN to Santa Ana, CA Bus Times

Departure date
Monday, Jun 16, 2025

Compare prices and tickets from Indianapolis, IN to Santa Ana, CA

Best time to book Indianapolis, IN to Santa Ana, CA travel

Virail Pro Tip ✌: Booking 10 days in advance save 10% on average

Best time to book cheap bus tickets from Indianapolis, IN to Santa Ana, CA

The cheapest Indianapolis, IN - Santa Ana, CA bus tickets can be found for as low as $109.22 if you’re lucky, or $129.97 on average. The most expensive ticket can cost as much as $161.34.

Find the best day to travel to Santa Ana, CA by bus

When travelling to Santa Ana, CA by bus, if you want to avoid crowds you can check how frequently our customers are travelling in the next 30-days using the graph below. On average, the peak hours to travel are between 6:30am and 9am in the morning, or between 4pm and 7pm in the evening. Please keep this in mind when travelling to your point of departure as you may need some extra time to arrive, particularly in big cities!

Services on board FlixBus and Greyhound from Indianapolis, IN to Santa Ana, CA
Compare services on board when travelling from Indianapolis, IN to Santa Ana, CA by bus.
Facilities FlixBus Greyhound
power_sockets Power sockets check check
luggage Luggage check check
food_and_drink Food and drink check cross
air_con Air conditioning check check
wifi WiFi check check
accessibility Accessibility check check
bicycle Bicycle check cross
entertainment_portal Entertainment Portal check cross
mobility_and_wheelchair_services landingPage.services.mobility_and_wheelchair_services check cross

Indianapolis, IN to Santa Ana, CA CO2 Emissions by Bus

Ecology
Train
202.32kg
Bus
216.77kg
Flight
578.05kg
Car
462.44kg

Anything we can improve?

Frequently Asked Questions

How much is a bus ticket from Indianapolis, IN to Santa Ana, CA?
A bus ticket from Indianapolis, IN to Santa Ana, CA is $336.01. However the price varies depending on how early you buy, and if it's peak time to travel. Occasionally you can find them for as cheap as $162.32.
What's the cheapest bus ticket from Indianapolis, IN to Santa Ana, CA?
The cheapest ticket you can get from Indianapolis, IN to Santa Ana, CA is $162.32. We recommend booking as early as possible and off-peak hours to get the cheapest ticket possible. Off-peak times are usually from 09:30 to 16:00, and after 19:00.
What's the distance between Indianapolis, IN and Santa Ana, CA by bus?
Indianapolis, IN to Santa Ana, CA is 2,890.27 km.
How long does the bus between Indianapolis, IN and Santa Ana, CA take?
Indianapolis, IN to Santa Ana, CA is on average 57 hrs 52 mins. However the fastest option will get you there in 47 hrs 40 mins.
Which companies operate from Indianapolis, IN to Santa Ana, CA?
The bus journey from Indianapolis, IN to Santa Ana, CA is covered by 1 operator(s). On Virail you can find these carriers that provide services on this route: FlixBus and Greyhound.
How many bus connections per day go from Indianapolis, IN to Santa Ana, CA?
Indianapolis, IN to Santa Ana, CA has 14 connection(s) per day on average.
What time does the first bus from Indianapolis, IN to Santa Ana, CA leave?
The earliest bus from Indianapolis, IN to Santa Ana, CA departs at 3:30 a.m.. However be sure to check with us the schedule on the day you want to leave as the time may differ.
What time does the last bus from Indianapolis, IN to Santa Ana, CA depart?
The latest bus from Indianapolis, IN to Santa Ana, CA departs at 11:55 p.m.. However be sure to check with us the schedule on the day you want to leave as the time may differ.
Should I book my ticket from Indianapolis, IN to Santa Ana, CA in advance?
If you can, we recommend booking your ticket as early as possible to ensure you get better savings. The cheapest bus ticket we have found is $162.32 but this may be subject to change depending on the day of travel, hour you wish to depart and how far in advance you book.
What's the fastest journey time between Indianapolis, IN to Santa Ana, CA by bus?
The fastest journey time by bus between Indianapolis, IN and Santa Ana, CA is 47 hrs 40 mins.
Is there a direct bus from Indianapolis, IN to Santa Ana, CA?
Yes, there is a direct bus between Indianapolis, IN and Santa Ana, CA.
What are the CO2 emissions for Indianapolis, IN to Santa Ana, CA by bus?
The bus journey from Indianapolis, IN to Santa Ana, CA creates 216.77kg of CO2 emissions.

Go local from Indianapolis, IN

Buses Indianapolis, IN - Chicago, ILBuses Indianapolis, IN - Columbus, OHBuses Indianapolis, IN - Louisville, KYBuses Indianapolis, IN - South Bend, INBuses Indianapolis, IN - Champaign, ILBuses Indianapolis, IN - Lafayette, IN

Trending routes

Buses Indianapolis, IN - New York, NYBuses Indianapolis, IN - TorontoBuses Indianapolis, IN - MontrealBuses Indianapolis, IN - Washington, DCBuses Indianapolis, IN - VancouverBuses Indianapolis, IN - Houston, TXBuses Indianapolis, IN - San Antonio, TXBuses Indianapolis, IN - Dallas, TXBuses Indianapolis, IN - Austin, TXBuses Indianapolis, IN - London, OntarioBuses Indianapolis, IN - Los Angeles, CABuses Indianapolis, IN - Niagara Falls

Weekend getaways from Indianapolis, IN

Buses Indianapolis, IN - Milwaukee, WIBuses Indianapolis, IN - St Louis, MOBuses Indianapolis, IN - Harrisburg, PABuses Indianapolis, IN - London, OntarioBuses Indianapolis, IN - Pittsburgh, PABuses Indianapolis, IN - Memphis, TNBuses Indianapolis, IN - Richmond, VABuses Indianapolis, IN - Kansas City, MOBuses Indianapolis, IN - Ann Arbor, MIBuses Indianapolis, IN - TorontoBuses Indianapolis, IN - Charlotte, NCBuses Indianapolis, IN - Washington, DC

International routes from Indianapolis, IN and nearby areas

Buses Indianapolis, IN - London, OntarioBuses Indianapolis, IN - Niagara FallsBuses Indianapolis, IN - VancouverBuses Indianapolis, IN - OttawaBuses Indianapolis, IN - TorontoBuses Indianapolis, IN - MontrealBuses Chicago, IL - London, OntarioBuses Chicago, IL - St. CatharinesBuses Columbus, OH - Niagara FallsBuses Chicago, IL - Niagara FallsBuses Champaign, IL - VancouverBuses Chicago, IL - Vancouver

Other destinations from Indianapolis, IN

Buses Indianapolis, IN - Phoenix, AZBuses Indianapolis, IN - Washington, DCBuses Indianapolis, IN - San Antonio, TXBuses Indianapolis, IN - Los Angeles, CABuses Indianapolis, IN - Austin, TXBuses Indianapolis, IN - Columbus, OHBuses Indianapolis, IN - Atlanta, GABuses Indianapolis, IN - Charlotte, NCBuses Indianapolis, IN - Seattle, WABuses Indianapolis, IN - Chicago, ILBuses Indianapolis, IN - Sacramento, CABuses Indianapolis, IN - Philadelphia, PA

Main routes to Santa Ana, CA

Buses Phoenix, AZ - Santa Ana, CABuses Washington, DC - Santa Ana, CABuses San Antonio, TX - Santa Ana, CABuses Los Angeles, CA - Santa Ana, CABuses Boston, MA - Santa Ana, CABuses Portland, OR - Santa Ana, CABuses Bakersfield, CA - Santa Ana, CABuses Las Vegas, NV - Santa Ana, CABuses Milwaukee, WI - Santa Ana, CABuses Chicago, IL - Santa Ana, CABuses St Louis, MO - Santa Ana, CABuses Philadelphia, PA - Santa Ana, CA

Related routes

Trains Santa Ana, CA - Indianapolis, INBuses Santa Ana, CA - Indianapolis, IN

Other popular routes

Buses Los Angeles, CA - TulsaBuses Cleveland, OH - Las Vegas, NVBuses Indianapolis, IN - Fayetteville, NCBuses Dallas, TX - Winston-Salem, NCBuses Las Vegas, NV - VancouverBuses Dallas, TX - Baton Rouge, LABuses Yuma, AZ - Bakersfield, CABuses Sacramento, CA - Columbus, OHBuses Manchester, NH - MontrealBuses Austin, TX - Burlington, VTBuses Columbus, OH - Milwaukee, WIBuses Indianapolis, IN - Wilmington, DEBuses Portland, ME - MontrealBuses Belleville - New York, NYBuses Abilene - London, OntarioBuses St Louis, MO - Phoenix, AZBuses Sudbury, Ontario - Rivière-du-LoupBuses Jacksonville, FL - Mobile, ALBuses Baltimore, MD - Niagara FallsBuses Indianapolis, IN - Memphis, TN