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Indianapolis, IN to St Louis, MO Bus

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11/11/2025
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Indianapolis, IN to St Louis, MO by bus

The journey from Indianapolis, IN to St Louis, MO by bus is 370.9 km and takes 4 hrs 25 mins. There are 6 connections per day, with the first departure at 3:35 a.m. and the last at 8:20 p.m.. It is possible to travel from Indianapolis, IN to St Louis, MO by bus for as little as $124.88 or as much as $139.29. The best price for this journey is $124.88.

Lowest Price $124.88
Journey Duration 4 hrs 25 mins
Connection per Day 6
Lowest Price $124.88
Highest Price $139.29
First Departure 3:35 a.m.
Last Departure 8:20 p.m.
Distance 370.9 km
Departure Indianapolis, IN
Arrival St Louis, MO
Carriers Greyhound Lines, Inc., Greyhound

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Best time to book cheap bus tickets from Indianapolis, IN to St Louis, MO

The cheapest Indianapolis, IN - St Louis, MO bus tickets can be found for as low as $135.76 if you’re lucky, or $161.55 on average. The most expensive ticket can cost as much as $200.56.

Find the best day to travel to St Louis, MO by bus

When travelling to St Louis, MO by bus, if you want to avoid crowds you can check how frequently our customers are travelling in the next 30-days using the graph below. On average, the peak hours to travel are between 6:30am and 9am in the morning, or between 4pm and 7pm in the evening. Please keep this in mind when travelling to your point of departure as you may need some extra time to arrive, particularly in big cities!

Services on board Greyhound from Indianapolis, IN to St Louis, MO
Compare services on board when travelling from Indianapolis, IN to St Louis, MO by bus.
Facilities Greyhound
wifi WiFi check
power_sockets Power sockets check
luggage Luggage check
air_con Air conditioning check
accessibility Accessibility check

Indianapolis, IN to St Louis, MO CO2 Emissions by Bus

Ecology
Train
25.96kg
Bus
27.82kg
Flight
74.18kg
Car
59.34kg

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Frequently Asked Questions

How much is a bus ticket from Indianapolis, IN to St Louis, MO?
A bus ticket from Indianapolis, IN to St Louis, MO is $132.08. However the price varies depending on how early you buy, and if it's peak time to travel. Occasionally you can find them for as cheap as $124.88.
What's the cheapest bus ticket from Indianapolis, IN to St Louis, MO?
The cheapest ticket you can get from Indianapolis, IN to St Louis, MO is $124.88. We recommend booking as early as possible and off-peak hours to get the cheapest ticket possible. Off-peak times are usually from 09:30 to 16:00, and after 19:00.
What's the distance between Indianapolis, IN and St Louis, MO by bus?
Indianapolis, IN to St Louis, MO is 370.9 km.
How long does the bus between Indianapolis, IN and St Louis, MO take?
Indianapolis, IN to St Louis, MO is on average 4 hrs 25 mins. However the fastest option will get you there in 3 hrs 55 mins.
Which companies operate from Indianapolis, IN to St Louis, MO?
The bus journey from Indianapolis, IN to St Louis, MO is covered by 1 operator(s). On Virail you can find these carriers that provide services on this route: Greyhound Lines, Inc. and Greyhound.
How many bus connections per day go from Indianapolis, IN to St Louis, MO?
Indianapolis, IN to St Louis, MO has 6 connection(s) per day on average.
What time does the first bus from Indianapolis, IN to St Louis, MO leave?
The earliest bus from Indianapolis, IN to St Louis, MO departs at 3:35 a.m.. However be sure to check with us the schedule on the day you want to leave as the time may differ.
What time does the last bus from Indianapolis, IN to St Louis, MO depart?
The latest bus from Indianapolis, IN to St Louis, MO departs at 8:20 p.m.. However be sure to check with us the schedule on the day you want to leave as the time may differ.
Should I book my ticket from Indianapolis, IN to St Louis, MO in advance?
If you can, we recommend booking your ticket as early as possible to ensure you get better savings. The cheapest bus ticket we have found is $124.88 but this may be subject to change depending on the day of travel, hour you wish to depart and how far in advance you book.
How many direct connections depart from Indianapolis, IN to St Louis, MO?
There are on average 6 direct connection(s) from Indianapolis, IN to go to St Louis, MO.
What's the fastest journey time between Indianapolis, IN to St Louis, MO by bus?
The fastest journey time by bus between Indianapolis, IN and St Louis, MO is 3 hrs 55 mins.
Is there a direct bus from Indianapolis, IN to St Louis, MO?
Yes, there is a direct bus between Indianapolis, IN and St Louis, MO.
What are the CO2 emissions for Indianapolis, IN to St Louis, MO by bus?
The bus journey from Indianapolis, IN to St Louis, MO creates 27.82kg of CO2 emissions.

Go local from Indianapolis, IN

Buses Indianapolis, IN - Chicago, ILBuses Indianapolis, IN - Columbus, OHBuses Indianapolis, IN - Louisville, KYBuses Indianapolis, IN - South Bend, INBuses Indianapolis, IN - Champaign, ILBuses Indianapolis, IN - Lafayette, IN

Trending routes

Buses Indianapolis, IN - New York, NYBuses Indianapolis, IN - TorontoBuses Indianapolis, IN - MontrealBuses Indianapolis, IN - Washington, DCBuses Indianapolis, IN - VancouverBuses Indianapolis, IN - Houston, TXBuses Indianapolis, IN - San Antonio, TXBuses Indianapolis, IN - Dallas, TXBuses Indianapolis, IN - Austin, TXBuses Indianapolis, IN - London, OntarioBuses Indianapolis, IN - Los Angeles, CABuses Indianapolis, IN - Niagara Falls

Weekend getaways from Indianapolis, IN

Buses Indianapolis, IN - Milwaukee, WIBuses Indianapolis, IN - Pittsburgh, PABuses Indianapolis, IN - Niagara FallsBuses Indianapolis, IN - London, OntarioBuses Indianapolis, IN - Buffalo, NYBuses Indianapolis, IN - Memphis, TNBuses Indianapolis, IN - Ann Arbor, MIBuses Indianapolis, IN - Kansas City, MOBuses Indianapolis, IN - Harrisburg, PABuses Indianapolis, IN - TorontoBuses Indianapolis, IN - Charlotte, NCBuses Indianapolis, IN - Washington, DC

International routes from Indianapolis, IN and nearby areas

Buses Indianapolis, IN - London, OntarioBuses Indianapolis, IN - Niagara FallsBuses Indianapolis, IN - VancouverBuses Indianapolis, IN - OttawaBuses Indianapolis, IN - TorontoBuses Indianapolis, IN - MontrealBuses Chicago, IL - London, OntarioBuses Chicago, IL - St. CatharinesBuses Columbus, OH - Niagara FallsBuses Chicago, IL - Niagara FallsBuses Champaign, IL - VancouverBuses Chicago, IL - Vancouver

Other destinations from Indianapolis, IN

Buses Indianapolis, IN - Phoenix, AZBuses Indianapolis, IN - Washington, DCBuses Indianapolis, IN - San Antonio, TXBuses Indianapolis, IN - Los Angeles, CABuses Indianapolis, IN - Austin, TXBuses Indianapolis, IN - Columbus, OHBuses Indianapolis, IN - Atlanta, GABuses Indianapolis, IN - Charlotte, NCBuses Indianapolis, IN - Seattle, WABuses Indianapolis, IN - Chicago, ILBuses Indianapolis, IN - Sacramento, CABuses Indianapolis, IN - Philadelphia, PA

Main routes to St Louis, MO

Buses San Antonio, TX - St Louis, MOBuses Washington, DC - St Louis, MOBuses San Jose, CA - St Louis, MOBuses Chicago, IL - St Louis, MOBuses San Francisco, CA - St Louis, MOBuses Charlotte, NC - St Louis, MOBuses Milwaukee, WI - St Louis, MOBuses Seattle, WA - St Louis, MOBuses Denver, CO - St Louis, MOBuses Houston, TX - St Louis, MOBuses Atlanta, GA - St Louis, MOBuses Dallas, TX - St Louis, MO

Related routes

Trains Indianapolis, IN - St Louis, MOTrains St Louis, MO - Indianapolis, INBuses St Louis, MO - Indianapolis, IN

Other popular routes

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