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San Francisco, CA to Santa Ana, CA Bus

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19/06/2025
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San Francisco, CA to Santa Ana, CA by bus

The journey from San Francisco, CA to Santa Ana, CA by bus is 608.31 km and takes 12 hrs 22 mins. There are 16 connections per day, with the first departure at 5:15 a.m. and the last at 11:25 p.m.. It is possible to travel from San Francisco, CA to Santa Ana, CA by bus for as little as $66.47 or as much as $162.14. The best price for this journey is $66.47.

Lowest Price $66.47
Journey Duration 12 hrs 22 mins
Connection per Day 16
Lowest Price $66.47
Highest Price $162.14
First Departure 5:15 a.m.
Last Departure 11:25 p.m.
Distance 608.31 km
Departure San Francisco, CA
Arrival Santa Ana, CA
Carriers Amtrak, FlixBus

San Francisco, CA to Santa Ana, CA Bus Times

Departure date
Thursday, Jun 19, 2025

Compare prices and tickets from San Francisco, CA to Santa Ana, CA

Best time to book San Francisco, CA to Santa Ana, CA travel

Virail Pro Tip ✌: Booking 10 days in advance save 10% on average

Best time to book cheap bus tickets from San Francisco, CA to Santa Ana, CA

The cheapest San Francisco, CA - Santa Ana, CA bus tickets can be found for as low as $109.22 if you’re lucky, or $129.40 on average. The most expensive ticket can cost as much as $161.34.

Find the best day to travel to Santa Ana, CA by bus

When travelling to Santa Ana, CA by bus, if you want to avoid crowds you can check how frequently our customers are travelling in the next 30-days using the graph below. On average, the peak hours to travel are between 6:30am and 9am in the morning, or between 4pm and 7pm in the evening. Please keep this in mind when travelling to your point of departure as you may need some extra time to arrive, particularly in big cities!

Services on board Amtrak, FlixBus and Greyhound from San Francisco, CA to Santa Ana, CA
Compare services on board when travelling from San Francisco, CA to Santa Ana, CA by bus.
Facilities Amtrak FlixBus Greyhound
quiet_zone Quiet zone check cross cross
wifi WiFi check check check
power_sockets Power sockets check check check
luggage Luggage check check check
accessibility Accessibility check check check
food_and_drink Food and drink check check cross
air_con Air conditioning check check check
bicycle Bicycle check check cross
sleeper_couchette Sleeper check cross cross
entertainment_portal Entertainment Portal cross check cross
mobility_and_wheelchair_services landingPage.services.mobility_and_wheelchair_services cross check cross

San Francisco, CA to Santa Ana, CA CO2 Emissions by Bus

Ecology
Train
42.58kg
Bus
45.62kg
Flight
121.66kg
Car
97.33kg

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Frequently Asked Questions

How much is a bus ticket from San Francisco, CA to Santa Ana, CA?
A bus ticket from San Francisco, CA to Santa Ana, CA is $128.19. However the price varies depending on how early you buy, and if it's peak time to travel. Occasionally you can find them for as cheap as $66.47.
What's the cheapest bus ticket from San Francisco, CA to Santa Ana, CA?
The cheapest ticket you can get from San Francisco, CA to Santa Ana, CA is $66.47. We recommend booking as early as possible and off-peak hours to get the cheapest ticket possible. Off-peak times are usually from 09:30 to 16:00, and after 19:00.
What's the distance between San Francisco, CA and Santa Ana, CA by bus?
San Francisco, CA to Santa Ana, CA is 608.31 km.
How long does the bus between San Francisco, CA and Santa Ana, CA take?
San Francisco, CA to Santa Ana, CA is on average 12 hrs 22 mins. However the fastest option will get you there in 9 hrs 5 mins.
Which companies operate from San Francisco, CA to Santa Ana, CA?
The bus journey from San Francisco, CA to Santa Ana, CA is covered by 2 operator(s). On Virail you can find these carriers that provide services on this route: Amtrak, FlixBus and Greyhound.
How many bus connections per day go from San Francisco, CA to Santa Ana, CA?
San Francisco, CA to Santa Ana, CA has 16 connection(s) per day on average.
What time does the first bus from San Francisco, CA to Santa Ana, CA leave?
The earliest bus from San Francisco, CA to Santa Ana, CA departs at 5:15 a.m.. However be sure to check with us the schedule on the day you want to leave as the time may differ.
What time does the last bus from San Francisco, CA to Santa Ana, CA depart?
The latest bus from San Francisco, CA to Santa Ana, CA departs at 11:25 p.m.. However be sure to check with us the schedule on the day you want to leave as the time may differ.
Should I book my ticket from San Francisco, CA to Santa Ana, CA in advance?
If you can, we recommend booking your ticket as early as possible to ensure you get better savings. The cheapest bus ticket we have found is $66.47 but this may be subject to change depending on the day of travel, hour you wish to depart and how far in advance you book.
How many direct connections depart from San Francisco, CA to Santa Ana, CA?
There are on average 3 direct connection(s) from San Francisco, CA to go to Santa Ana, CA.
What's the fastest journey time between San Francisco, CA to Santa Ana, CA by bus?
The fastest journey time by bus between San Francisco, CA and Santa Ana, CA is 9 hrs 5 mins.
Is there a direct bus from San Francisco, CA to Santa Ana, CA?
Yes, there is a direct bus between San Francisco, CA and Santa Ana, CA.
What are the CO2 emissions for San Francisco, CA to Santa Ana, CA by bus?
The bus journey from San Francisco, CA to Santa Ana, CA creates 45.62kg of CO2 emissions.

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